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Small Animal Section: No.
11
TABLE : A GRADING
SYSTEM FOR LYMPHOPLASMACYTIC GASTROENTERITIS:
|
DESCRIPTION |
GRADE |
DESCRIPTION OF RELEVANT LESIONS |
|
NORMAL |
0-2 |
LAMINA PROPRIA
Lymphocytes and plasma cells either present focally affecting
25 - 75% of glands or diffusely with less than 3-4 cells in array between
glands
SUPERFICIAL EPITHELIUM
Normal with infrequent intraepithelial lymphocytes
CRYPT VILLUS UNIT
Normal
MISCELLANEOUS
No fibrosis or oedema present |
| MILD |
2.5-3 |
LAMINA PROPRIA
Mild diffuse to moderate focal lymphoplasmacytic infiltrates;
5 - 8 cells in array between glands
SUPERFICIAL EPITHELIUM
Normal columnar epithelium with mild numbers of
intraepithelial lymphocytes
CRYPT VILLUS UNIT
Normal
MISCELLANEOUS
Mild oedema and/or fibrosis |
|
MODERATE |
3.5-4 |
LAMINA PROPRIA
Moderate diffuse to severe focal lymphoplasmacytic
infiltrates; > 8 cells in array between glands
SUPERFICIAL EPITHELIUM
Flattening of the absorptive epithelial cells
Moderate numbers of intraepithelial lymphocytes
Decreased numbers of goblet cells
Multifocal erosions
CRYPT VILLUS UNIT
Slight blunting of the villi
Slight decreased numbers of crypts and glands
Separation of glands or crypts by moderate cell infiltrates and/or fibrosis
MISCELLANEOUS
Moderate oedema and fibrosis |
|
SEVERE |
4.5-5 |
LAMINA PROPRIA
Severe diffuse lymphoplasmacytic infiltrates; > 8 cells in
array between glands
SUPERFICIAL EPITHELIUM
Cuboidal absorptive epithelial cells
Moderate numbers of intraepithelial lymphocytes
Marked decrease in numbers of goblet cells
Multifocal to coalescing erosions/ulcerations
CRYPT VILLUS UNIT
Fusion and blunting of villi
Lymphangiectasia
Partial to complete obliteration of glands and crypts by cell infiltrates
and/or fibrosis
MISCELLANEOUS
Severe oedema and fibrosis |
References:
 |
Dennis, JS et al Lymphocytic/plasmacytic
gastroenteritis in cats: 14 cases (1985-1990). Journal of the American
Veterinary Medical Association 200: 11, 1712-1718 |
|
Ettinger, SJ & Feldman EC
Textbook of Veterinary Internal Medicine 5th Edition, Volume 2: Chapters 137 &
138 , 1182 – 1257 |
|
Roth L et al, A grading system
for lymphocytic plasmacytic colitis in dogs. Journal of Veterinary Diagnostic
Investigation 2: 257 - 262 (1990) |
Compiled
by dr Lorna Bolton and dr Emily
Lane for VetPath
For further information contact:
VetPath Veterinary Pathologists
PO Box 8464, Pretoria 0001
Tel: (012) 529 8345/6
e-mail:
info@vetpath.co.za
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