Causes of infectious abortion

 

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Large animal section: No. 2

CAUSES OF INFECTIOUS ABORTION IN CATTLE IN SOUTH AFRICA

Reviewed by Dr Pete Irons

Disease Clinical features Abortion rate Abortion time   Placenta Foetus Diagnostic confirmation
Brucellosis      (B. abortus) Contagious abortion Abortion. Oral infection. 90% cows are carriers. Zoonosis High, in susceptible herds 6-9 months + neonatal death Leathery & opaque placenta with oedema.  Necrosis of cotyledons. Pneumonia. S/c oedema. Pleuritis. Large % no lesions Culture of foetal organs. Elisa, Rose Bengal, Milkring, Complement fixation serology tests. Stamps cytology. Histopath.
Campylobac-teriosis              (Campylobacter foetus ) Infertility.  Irregular moderately prolonged dioestrus. Rare abortions Low < 5%, may be up to 20% 3-5 months Semi-opaque, little thickening. Petechiae, localized avascularity and oedema Flakes of pus on peritoneum. Usually no lesions Culture of foetal stomach, placenta and uterine exudates. Bull sheath wash / scrapings. (Steves TM) 
Leptospirosis (L.interrogans pomona and L. hardjo etc.) Abortion may occur at acute febrile stage, or  without illness 0 - 30% Late, 6 months + & neonatal Avascular placenta yellowbrown cotyledons,  oedema. Placentitis Foetal death common - autolytic foetus. Icterus may occur Isolation difficult. Direct examination of urine of cow. Positive serum agglutinatin test 14-21 days after fever. Histopath : Warthin-Starry stain
Trichomoniosis Tritrichomonas foetus Infertility - return to heat at 4-5 months, abortion and pyometra Moderate,    5 – 30% 2-4 months Flocculent material and clear, serous fluid in uterine exudates. Pyometra common Foetal maceration & mummification. Culture of foetal stomach and uterine exudates within 24 hours of abortion. Culture bull sheath wash / scrapings (Steves TM)
Neosporosis (Neospora spp.) Sporadic or abortion storms. Repeated abortions High in dairy cows 4 - 6 months No macro lesions Autolyzed and rarely white foci in muscle and heart Histopathology and histochemistry on formalin fixed foetal brain tissue. Serology.
Bovine viral diarrhoea (BVD) < 125 days resorp.               > 125 days abortion. Infertility. Clinical mucosal disease Sporadic high abortion rate 4 - 9 months & neonatal No macro lesions Abortion. Congenital malformations eye and brain. Antigen detection  Eliza capture, Histochemistry on formalin tissue. Viral culture. Serology  (negative titre may be carrier) IFA.
Bovine rhinotra-cheitis (IBR) IBR signs, fever, abortions High in  un-vaccinated herds > 4 months Placentitis necrotic colyledons Autolytic foetus. Necrotic liver foci. Excess fluid in body cavities Culture placenta, abomasum & kidney. Serology if unvaccinated Bronchopneumonia on PM.  Histochemistry on formalin tissue
Actinomyces pyogenes Sporadic abortions, endometritis, pyometra, placentitis  Low, 5% or less  Last tri-mester  Placentitis with red - brown exudate & micro-abscesses of cotyledons Fibrinous poly-serositis. Broncho-pneumonia Culture the placenta and abomasum. (Gram +)  A bronchopneumonia is present with histopathology. 
Mycoses (Aspergillus, Absidia, etc sp.) Rare sporadic abortion Unknown. Low % of all abor-tions  4 -7 months Necrotic cotyledons- yellow & soft. Mycotic leathery plaques present Fresh foetus. Skin plaques  or diffuse white areas   Cytology of cotyledon, foetal stomach for fungal hyphae. Culture. Histo-pathology of skin & other lesions
Listeriosis            Listeria mono-cytogenes Sporadic disease with or without septicaemia Low.  Max 15% 6 - 8 months Necrotic placentitis Autolysis. Micro-abscesstion of the liver  Culture from foetal stomach or placenta. Histopathology of necrotic hepatitis.
Chlamydiosis  Chlamydophila abortus.  Abortions.Diarrhoea, pneumonia, arthritis in neonatal calves. Epizootic in cattle Sporadic high abortion rate 6 - 9 months No macro lesions Anasarca, lymph-adenopathy,tracheal petechea Isolation from foetus. PCR test on organ material. Gimenez cytology. IFA antigen detection. Histopathology. 
The importance of Mycoplasma, Ureaplasma, Coxiella,Cowdria,Babesia,Salmonella,Haemophilus,Parainfluenza, Rift Valley fever, Orbi-, Simbu-virus,etc is still undetermined.  The cause of abortion is undiagnosed and / or non-infectious in 60 - 70% of cases.

For further information contact:

VetPath Veterinary Pathologists
P.O. Box 8464
Pretoria 0001
Tel: (012)
529 8345/6
e-mail: info@vetpath.co.za

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Last modified: Friday June 25, 2004